Purpose Prostate problems, such as prostate cancer, and benign prostate hyperplasia have been recognized as problems largely related to androgens and genetic factors. They affect a large fraction of the elderly population, contributing significantly to morbidity and mortality. Therefore, the purpose of this review paper was to investigate a therapeutic strategies for prostate cancer and benign prostate hyperplasia. Methods In order to determine the therapeutic exercise strategies for prostate cancer and benign prostate hyperplasia, previous literature was reviewed with MEDLINE, PubMed, and Scopus databases. Results Prostate cancer and its associated treatments can cause significant and lasting morbidities, such as cardiovascular and sexual dysfunctions. Various interventions have attempted to prevent or mitigate these dysfunctions. This review summarizes the available evidence concerning the effects of exercise training on male sexual health in the cancer prevalent population. Smoking cessation, regular exercise, and maintaining healthy weight are important public health targets for intervention. Importantly, several lifestyle modifications may lower the risk of developing more aggressive cancer or offer survival benefits to prostate cancer patients. Conclusions In this review article, physical exercise training can increase apoptosis markers in the prostate, suggesting exercise training as a potential novel therapeutic strategies for treating prostate cancer and benign prostate hyperplasia. Future studies in more advanced and varied prostate cancer populations are required to ascertain the duration, intensity and frequency of exercise that optimizes the effects of exercise training on prostate cancer and benign prostate hyperplasia.
Purpose The purpose of this study was to investigate changes of the cardiovascular system by comparing heart rate (HR) and blood responses to exercise in younger and older adult dogs and to verify the value of dogs as aging model in exercise science research. Methods A total of 11 healthy beagles were divided into 2 groups according to age: younger adult dogs (1~2 years old, 7 animals) and older adult dogs (9~11 years old, 4 animals). Each animal exercised on the treadmill for 25 minutes, twice a week, and for 4 weeks. The exercise intensity was gradually increased by applying four different protocols. Resting HR, HR during exercise, and HR recovery time were determined as HR parameters. Biochemical analysis was performed on blood samples. The independent Student’s t-test and one-way ANOVA were used to analyze the mean difference of each variable. The associations between age and HR parameters were determined using Spearman‘s analysis. Results Older adult dogs showed higher HRs during rest and exercise than younger adult dogs. HR recovery time was significantly longer in older adult dogs than in younger adult dogs. A strong positive relationship was observed between beagles’ age and resting HR, HR during exercise, and HR recovery time, respectively. The heart rate response to the treadmill exercise was similar between the 1st week and 4th week in younger and older adult dogs. Exercise significantly reduced the white blood cell level in older adult dogs and increased the alkali phosphatase level in younger adult dogs. Conclusions The results of this study demonstrated that short-term treadmill exercise may have a positive effect on the aerobic capacity, inflammation, and bone formation, suggesting that dogs are valuable as aging model in exercise science research.
Purpose The purpose of this study was to investigate the effect of treadmill exercise and MitoQ treatment on NADPH oxidase, antioxidation and vascular function-related factors in aortic of D-galactose-induced aging rats. Methods To induce the animal model of aging, D-galactose was diluted in saline, and a dose of 100mg /kg was intraperitoneally injected into Sprague-Dawley rats once a day for a total of 10 weeks. Rats were divided into five groups: Control group (CON, n=9), D-galactose control group (DC, n=9), D-galactose+MitoQ group (DM, n=9), D-galactose+Exercise group (DE, n=9), D-galactose+MitoQ + Exercise group(DME, n=9), and treadmill exercise was conducted for 5 days/week during 8 weeks with gradual increase of intensity. MitoQ treatment was intraperitoneally injected at a concentration of 100μM/kg twice a week for 8 weeks during the research period. Results The result showed that treadmill exercise and MitoQ treatment decreased the expression of NADPH oxidase level and increased antioxidant enzyme such as SOD-2, catalase. It lead to positive effects such as increasing the level of eNOS, a protein involved in vascular function while decreasing the level of VCAM-1. In addition, as a result, it showed the structurally reduced intima-media thickness. Conclusions It can be concluded that treadmill exercise and MitoQ treatment are effective in ameliorating and treating vascular dysfunction resulting from aging.
[Purpose] This study aimed to examine the effects of complex physical training on exercise and football performances in youth football players. [Methods] The subjects (n=16) were randomly assigned to either a complex physical training group (CPG, n=8) or a control group (CON, n=8). CPG was performed the complex physical training for 50 minute per day, and 2∼3 times per week, for 8 weeks. Exercise performance (health related physical fitness, skill related physical fitness, Y-balance and functional movement screen; FMS) and football performance (juggling, speed dribbling, shot passing, long kick and triple hop) were measured before and after 8 weeks complex physical training. [Results] Sit-up (p=0.002), sit and reach (p=0.040), 50-m run (p=0.031), side step (p=0.005), single-leg standing with eyes closed (p=0.040), plank (p=0.023), dominant composite score (p=0.002) and non-dominant composite score (p=0.005), deep squat (p=0.009), inline lunge (p=0.042), active straight leg-raise (p=0.015), rotary stability (p=0.049), total score(p=0.001), speed dribbling (p=0.030), dominant triple hop (p=0.001) and non-dominant triple hop (p=0.032) were statistical significant interactions between group and time. [Conclusion] Our findings indicate that complex physical training has beneficial effects on performance improvement of exercise and football in youth football players.
Purpose The purpose of this study was to analyze the effect of push-up plus exercise(PUPE) on stabilization of the scapula and to use it as basic data for shoulder rehabilitation program. Methods In this study, research papers were collected using Research Information Sharing Service(RISS) and Pub-Med Central.(PMC) as a search term for scapular stabilization, push - up plus, shoulder joint injury rehabilitation and scapular stabilization exercise. Also, it was used as basic data of literature analysis. The collected data were classified into the structure and movement of the scapula and shoulder, kinesiologic relation of the scapula and the mechanism of injury, and the effect of push-up plus Results Serratus anterior is a typical stabilizing muscle, and it forms a force couple with the upper and lower trapezius to control the movement of the scapula. The PUPE is an effective exercise method to selectively strengthen serratus anterior, which are the stabilizing muscles of the scapula, and is an exercise method that is also useful for correcting the wrong postures and movements because of hypertonus upper trapezius. In addition, various conditions such as application posture, arm position, and ground instability were suggested during PUPE. Conclusion The results of this study confirmed that PUPE is an effective program for scapula stabilization in the rehabilitation of shoulder injuries and injured patients and athletes. The PUPE will be used as a rehabilitation exercise program for patients and athletes who need rehabilitation of the shoulder joint.
This study was aimed at investigating the effect of head-tilt angle on autonomic nerve modulation immediately after a single bout of exercise in twenty-three healthy young males(age 21.96 ± .4 yrs). Post-exercise HRV was measured on supine(SUP), -15°head-down tilt(HDT), and +15°head-up tilt(HUT) followed by 20 min aerobic exercise with moderate intensity(40% of VO2max). As results, heart rate recovery during post-exercise on each tilt angle(SUP vs. HDT vs. HUT) had no significant difference(p> .05). Also, there were no significant difference in time and nonlinear domain index of HRV. On spectral analysis; however, frequency domain index(HF, LF/HF ratio, HF/TP ratio, HF nu, LF nu) had significant difference(p< .05) on each tilt angle at recovery. Especially, PNS reactivation index (HF, HF/TP ratio, HF nu) had significant increase on HDT compared to HUT(p<. 05) while SNS activation index (LF/HF ratio, LF nu) had significant decrease on HDT compared to HUT(p<. 05). Furthermore, there were significant interaction between recovery time elapsed and each tilt angle (except for HF/TP ratio). In conclusion, -15°head-down tilt promotes the effective cardiac vagus nerve reactivation immediately after a single bout of aerobic exercise.
It has been reported that continuous exercise and bright light exposure improved resistance to stress and reduced depression and anxiety, which were attributed to enhancing neurotransmitter GABA exocytosis and stimulating neurogenesis. In this study, the effects of treadmill exercise and bright light exposure on the expression of GABAAreceptor activity, calcineurin and calcineurin calcium signaling pathway-depended NFATc4, neurogenesis-related protein Cdk5 and specific regulator factor of Cdk in neurogenesis p35 in the hippocampus of rats were investigated by western blot assay. The expression of GABAAreceptor, Cdk5 and p35 significantly increased in the exercise+light group compared to the control group and the light group. The expression of KCC2 and NFATc4 significantly increased in the exercise+light group compared to all the other groups. And the expression of calcineurin significantly increased in the exercise+light group compared to the control group. The overall results showed that exercise and bright light stimulated neurogenesis of the hippocampus in rats and had positive effects on improving the brain neuronal function.
Whether a nocturnal exercise with concomitant increase of body temperature (Tb) would intensify circadian phase delay compare to exercise with a suppressed Tb increase was examined. Seven healthy men (20.57 ± 2.88 yrs, 174.43 ± 4.05 cm, 70.13 ± 6.07 kg, 10.74 ± 1.92% fat) participated in two tests. Each lasted 5-days. On the day of 1 of each test, subjects maintained habitual sleep time (23:00-07:00, 0.2 lux) in laboratory. From day 2 thru 5, they biked for 60 min at 55% of maximal capacity beginning at 01:30 (15 lux). Then they went to bed at 04:00 and woke at 12:00. During test, they exercised either at 26℃ with elevating Tb (ET) or at 17℃ with cooling devices for suppressing Tb (ST). Two tests were counter balanced and separated by 2 weeks. During exercise, rectal (Tre) and skin (Tsk) temperatures, and heart rate were continuously recorded. Body weight changes during exercise were measured. Urine volume and saliva sample were collected. Blood samples were taken at 23:00, 03:30, 07:00, and 12:00 on day 1 and 5 of tests and analyzed for melatonin. The average weight loss for 4 days of exercise in ET and ST was 0.62 ± 0.09 and 0.22 ± 0.07 kg, respectively (p<.001). Tre increased during exercise but not different between conditions. Tsk maintained at 32℃ in ET and 24℃ in ST (p<.001). Tb were higher in ET than ST during exercise (p<.05). The average total urine volume passed was 0.07 ± 0.07 in ET and 0.11 ± 0.07 liter in ST (p<.05). The melatonin concentration at day 1 was 23 ± 26, 107 ± 45, 98 ± 46, and 14 ± 5 in ET and 18 ± 10, 108 ± 65, 103 ± 75, and 14 ± 12 pg/ml in ST for each time period. At day 5, it was 9 ± 3, 64 ± 41, 122 ± 73, and 54.1 ± 17.8 in ET and 8 ± 1, 68 ± 21, 111 ± 52, and 32 ± 14 pg/ml in ST. Differences of melatonin between ET and ST at day 5 of 12:00 as well as between day 1 and 5 at 12:00 of both conditions were noticed (p<.05). Salivary cortisol and immunoglobulin-A were not different. A nocturnal exercise induced a circadian phase delay in both conditions. However, body temperature increase during exercise intensified the shift indicating the importance of thermal load during exercise for circadian shift.
The purpose of this study was to examine the intensity of horseback riding as exercise (heart rate, oxygen intake, respiration exchange ratio, metabolism, energy expenditure) according to the tread of a horse such as walking, rising trotting, sitting trotting, and cantering. In this study, the subjects were 15 amateur horse riders. They participated in a 4-stage process(riding while the horse was walking, rising trotting, sitting trotting, and cantering) while wearing gas masks and heart rate belts for 5 minutes during each stage. Through this study, the average of heart rate, oxygen intake, respiration exchange ratio, metabolism, and energy expenditure in each stage of riding was attained and compared. The result of this study can be summarized as follows. First, the intensity of exercise by horse riding is significantly different depending on the tread of a horse. The intensity of exercise is increased as the speed of the horse's movements increased. Trotting and cantering show higher intensity than walking. Among the different treads of a horse, walking can be categorized as having an intermediate intensity of exercise, whereas trotting and cantering are categorized into a higher intensity. However, there are no significant differences in intensity between trotting and cantering. Second, there are no significant differences between male female participants in terms of intensity of exercise, but there are differences in the energy consumption per minute. The weight differences between male and female participants may be what cause this difference.
The purpose of this study is to investigate the further direction of molecular biological studies, the advantages and limitations of assaying samples, and variables in figuring out the details of domestic and overseas studies verified through cell and molecular biological analysis in order to analyze the effect of concurrent training. The analysis study was limited to domestic and overseas literature, which investigated the effect of combined training using molecular biological analysis among studies to date. The study was reclassified by specialty, composed of professors of physical education and doctors of exercise physiology. The final selected study analyzed the subject and the trend of studies in terms of comprehensive perspectives. In detail, it analyzed hormonal and enzymatic changes in criteria such as leptin, 5-HT, ACTH(adrenocorticotropic hormone), cortisol, testosterone, GH(growth hormone), LDH(lactate dehydrogenase), CPK(creatine phosphokinase), antioxidants in blood samples and protein, and enzymatic and morphologic changes in for CRP, VEGF(vascular endothelial growth factor), PAI-1(plasminogen activator inhibitor-1), MAD(malondialdehyde), carnosin, and SDH(succinate dehydrogenase), the area of muscle fibers, ratio of type Ⅰ/Ⅱ muscle fiber and capillary proportion per muscle fiber in the extracted muscle by biopsy, for example. Finally, urine samples, and hormonal changes (like cortisol), were analyzed. The results of the analysis of domestic and overseas studies according to combined training has shown that this training has more varied effects than single training and lower improvement by interference effect or magnifying the effect of one type of training amongst the combined training types appears, rather than higher improvement through combined trainings. Therefore, it should be investigated in view of performance improvements relating to the characteristic of sports.
