Purpose The purpose of this study was to investigate the effects of regular vigorous- and moderate-intensity aerobic exercise on serum brain-derived neurotrophic factor (BDNF) level, aging- and lifestyle disease-related blood components in middle-aged women. Methods The participants were recruited from a total of 19 physically healthy people aged 50-59 years, and were randomly divided into vigorous-intensity aerobic exercise (VIAE, n = 10) and moderate-intensity aerobic exercise (MIAE, n = 9) group. The participants were performed vigorous- and moderate-intensity aerobic exercise three times a week for eight weeks, and body composition measurement, graded exercise test, blood collection were performed before and after. Results Mean exercise time was significantly longer in the MIAE group than in the VIAE group. The V̇O2max was significantly higher in the VIAE group than in the MIAE group. Body weight, BMI, and body fat percentage were significantly lower than pre both groups. The BDNF concentration was significantly higher in the VIAE group than in the MIAE group. The dehydroepiandrosterone sulfate (DHEA-s) and insulin-like growth factor-1 (IGF-1) concentration were significantly higher than pre both groups. The free fatty acid and triglyceride concentrations were significantly lower than pre both groups, and HDL-C concentrations were significantly higher than pre both groups. Conclusions Vigorous-intensity aerobic exercise not only increases maximal oxygen uptake and blood BDNF level in middle-aged women, but also induces positive changes in aging-related hormones and lifestyle-related blood variables.
The purpose of this study was to examine whether the difference between ingestion of nutrition supplements for 8 weeks can regulate physical activities and fatigue recovery. Fifty one middle-aged women participated in this study and were divided into placebo, ingestion of 20g energy supplement and ingestion of 40g energy supplement groups. Energy supplement mainly consists of carbohydrates and proteins. All subjects take in this supplement one time per a day for 8 weeks. Physical activity and fatigue recovery were measured before and after ingestion of energy supplement for 8 weeks by using the Wingate anaerobic and a blood tests. In the Wingate anaerobic test, the peak power(p<.01) and average power(p<.05) were significantly increased in ingestion of 20 and 40g supplement groups compared to the placebo group. Although concentrations of lactate and growth hormone in the blood didn’t show a significant differences among groups, blood concentrations of cortisol and ammonia were further enhanced in ingestion of 20 and 40g supplement groups compared to the placebo group(p<.001). The results of present study provide evidence that energy supplement mixed with carbohydrates and proteins may be effective to increase physical activity as well as to reduce blood concentration of fatigue-related factors after exercise.
