The frailty, characterized by reduced physiological function is closely related to a fall, disability, institutionalization, hospitalization, and mortality in the elderly. A reduced physical fitness is a major phenotype of the frailty. The purpose of this study was to investigate the relationship among pre-frailty, physical activity (PA) and functional fitness in the community dwelling elderly women. The study participants were elderly women (n=338, 70.6±4.2years) aged over 65 who took part in the Korean Healthy Fitness Criteria study for the National Fitness Award Project in 2015. The pre-frailty was defined using the Cardiovascular Health Study frailty criteria. PA was assessed using the International PA Questionnaire (IPAQ). The participants were classified as regular PA participants if they meet the World Health Organization (WHO) PA recommendation for the elderly. Functional fitness was assessed using the composite of the National Fitness Award fitness testing for the elderly. Quality of life was evaluated using EuroQoL visual analogue scale and WHO quality of life assessment. As the results, the pre-frail elderly women were significantly older and obese (body mass index, percent body fat, waist circumference) than the healthy elderly. The pre-frail elderly presented significant decreases in walking, moderate intensity, and total PA compared to the healthy elderly even after adjusted for age and percent body fat. However, no significant difference was found in vigorous-intensity activity between the pre-frail and healthy elderly. Also, the pre-frail elderly women showed the decrease in functional fitness and quality of life compared to the healthy elderly. Regular PA was associated with high levels of muscular endurance and coordination in healthy and pre-frail elderly. In pre-frail elderly, high levels of cardiorespiratory endurance was associated with PA. In conclusion, regular PA is inversely associated with fitness decline in healthy and pre-frail community-dwelling elderly women. Regular PA might attenuate fitness decline in pre-frail elderly women.
Purpose The purpose of this study was to examine the effects of 16 weeks’ combined exercise training on insulin resistance, inflammatory markers, oxidative stress, leukocyte telomere length, body composition, and daily living fitness in elderly women with type 2 diabetes mellitus (DM). Methods Twenty-eight participants were randomly assigned into one of two groups, i.e., exercise training group (EX: n=14) and control group (CON: n=14). Subjects in EX participated in 3 sessions of 60 min-combined exercise for 16 weeks, whereas subjects in CON were asked to maintain their normal life pattern during the same period. The variables regarding insulin resistance, inflammatory markers, oxidative stress, leukocyte telomere length, body composition, and daily living fitness were measured and compared between two groups as well as between pre-post test utilizing a repeated two-way ANOVA. Results Main results were as follows: 1) Fasting plasma insulin and HOMA-IR tended to decrease in EX, whereas increased significantly in CON. 2) IL-6, TNF-α, hs-CRP decreased in EX, but the changes were not statistically significant. 3) MDA increased significantly and GPx decreased significantly in both EX and CON. 4) Leukocyte telomere length increased significantly in EX. 5) Fat-free mass increased in EX, whereas fat mass and percent body fat decreased significantly in EX. 6) Arm curl, chair stand, sit & reach, tandem test, 10m walking speed, and up & go improved significantly in EX. Conclusion It was concluded that the combined exercise for 16 weeks had a positive effect on improving insulin resistance, increasing leukocyte telomere length, as well as enhancing body composition and daily living fitness in elderly women with type 2 diabetes.
