The purpose of this study was a investigate the endothelial function of prehypertensive during dynamic exercise. Hypothesis of this study was to impair the endothelial function in prehypertensive compared to normtensive during dynamic handgrip exercise. Eleven healthy prehypertension (24±2 yrs) and ten healthy normotensive (25 ± 2 yrs) were recruited in this study. Participants were performed dynamic handgrip exercise in one contraction per second at 30% of maximum voluntary contraction for three minutes. Vascular (blood vessel diameter, blood flow) and cardiar response (stroke volume, heart rate and cardiac output) were measured at rest and during exercise. Flow mediated dilation (FMD) was decrease significantly in prehypertensive less than normotensive (p<0.05) at rest, and vasodilation of prehypertensive was reduced significantly less than normitensive during exercise (p<0.05). All the cardiovascular responses were aot significantly different at rest and during exercise between prehypertensive and normotensive. These results suggest that endothelial function is impaired in prehypertensive compared to in normotensive
Purpose The purpose of this study was to investigate the effect of treadmill exercise and MitoQ treatment on NADPH oxidase, antioxidation and vascular function-related factors in aortic of D-galactose-induced aging rats. Methods To induce the animal model of aging, D-galactose was diluted in saline, and a dose of 100mg /kg was intraperitoneally injected into Sprague-Dawley rats once a day for a total of 10 weeks. Rats were divided into five groups: Control group (CON, n=9), D-galactose control group (DC, n=9), D-galactose+MitoQ group (DM, n=9), D-galactose+Exercise group (DE, n=9), D-galactose+MitoQ + Exercise group(DME, n=9), and treadmill exercise was conducted for 5 days/week during 8 weeks with gradual increase of intensity. MitoQ treatment was intraperitoneally injected at a concentration of 100μM/kg twice a week for 8 weeks during the research period. Results The result showed that treadmill exercise and MitoQ treatment decreased the expression of NADPH oxidase level and increased antioxidant enzyme such as SOD-2, catalase. It lead to positive effects such as increasing the level of eNOS, a protein involved in vascular function while decreasing the level of VCAM-1. In addition, as a result, it showed the structurally reduced intima-media thickness. Conclusions It can be concluded that treadmill exercise and MitoQ treatment are effective in ameliorating and treating vascular dysfunction resulting from aging.
The purpose of this study is to investigate the further direction of molecular biological studies, the advantages and limitations of assaying samples, and variables in figuring out the details of domestic and overseas studies verified through cell and molecular biological analysis in order to analyze the effect of concurrent training. The analysis study was limited to domestic and overseas literature, which investigated the effect of combined training using molecular biological analysis among studies to date. The study was reclassified by specialty, composed of professors of physical education and doctors of exercise physiology. The final selected study analyzed the subject and the trend of studies in terms of comprehensive perspectives. In detail, it analyzed hormonal and enzymatic changes in criteria such as leptin, 5-HT, ACTH(adrenocorticotropic hormone), cortisol, testosterone, GH(growth hormone), LDH(lactate dehydrogenase), CPK(creatine phosphokinase), antioxidants in blood samples and protein, and enzymatic and morphologic changes in for CRP, VEGF(vascular endothelial growth factor), PAI-1(plasminogen activator inhibitor-1), MAD(malondialdehyde), carnosin, and SDH(succinate dehydrogenase), the area of muscle fibers, ratio of type Ⅰ/Ⅱ muscle fiber and capillary proportion per muscle fiber in the extracted muscle by biopsy, for example. Finally, urine samples, and hormonal changes (like cortisol), were analyzed. The results of the analysis of domestic and overseas studies according to combined training has shown that this training has more varied effects than single training and lower improvement by interference effect or magnifying the effect of one type of training amongst the combined training types appears, rather than higher improvement through combined trainings. Therefore, it should be investigated in view of performance improvements relating to the characteristic of sports.
