Purpose The purpose of this study was to investigate the effect of a 10-week aerobic exercise training on cardiovascular function, atherosclerosis, and vascular endothelial function in elderly women. Methods Twenty impaired fasting glucose (IFG) and normoglycemic elderly women volunteered to participate in the study. The participants in aerobic exercise training group (TR: n=9) completed 20-40 minutes of aerobic exercise program at 30-50% HRR for 3 times per week during 10 weeks. The participants in control group (CON: n=11) were asked to maintain their normal life pattern during the same intervention period. Results Main results of the study were as follows: 1) There were no significant main effect or interaction in body weight, fat-free mass, fat mass, percent body fat, and body mass index. 2) There were no significant main effect or interaction in heart rate, stroke volume, cardiac output, total peripheral resistance (TPR), systolic blood pressure, diastolic blood pressure, mean arterial blood pressure, pulse pressure, and rate pressure product. However, interaction between group and test in TPR was close to statistically significant level (P =.054), and it tended to be decreased in TR group. 3) There was a significant main effect of test in high sensitivity C-reactive protein(hs-CRP), it tended to be decreased in TR group. There were no significant changes in total cholesterol(TC)/high density lipoprotein-cholesterol (HDL-C) ratio, triglyceride/HDL-C ratio, and low density lipoprotein-cholesterol/HDL-C ratio. 4) There were significant main effect of group, main effect of test, as well as interaction between group and test in % flow mediated dilation(FMD), and it increased significantly (P<.01) in TR group. Nitric oxide tended to be increased in TR group, even though it did not change significantly in both groups. Conclusions It was concluded that the 10-week aerobic exercise training would be beneficial for improvement of vascular endothelial function, resulting from the decrement of total peripheral resistance.
This study was designed to investigate the effects of increment of physical activity for 12 weeks through aerobic exercise training or change from own vehicle to public transportation for commuting on physical fitness, insulin resistance, inflammatory markers, and liver function in middle-aged men. Forty-four subjects, aged 30-50 yrs, were randomly assigned to either one of three groups, i.e., aerobic exercise training group (TR: n=14), change to public transportation group (PT: n=15), or control group (CON: n=15). Subjects in TR performed aerobic exercise for 30 min per sessions, three sessions per week, subjects in PT changed from their own vehicle to public transportation for commuting, and subjects in CON maintained their life patterns during the same intervention period. Physical fitness, insulin resistance, inflammatory markers, and liver function were measured at pre- and post-test, and the data were analyzed by repeated two-way ANOVA. Main results of the present study were as follows: 1) All variables related to physical fitness improved significantly in TR. Right grip strength, standing long jump, side step test, and sit-and-reach improved significantly in PT. 2) Although there were no significant changes in all variables related to insulin resistance, the variables tended to be improved in TR and PT. 3) TNF-α decreased significantly in TR and PT. IL-6 and CRP tended to be improved in TR and PT; however, the changes did not reach statistical significant level. 4) ALT decreased significantly in PT. AST and γ-GT tended to be improved in TR and PT; however, the changes did not reach statistical significant level. It was concluded that the 12 weeks of change to public transportation as well as aerobic exercise training would be beneficial for physical fitness and inflammatory markers. These interventions also would be possible to improve insulin resistance and liver function. The increment of physical activity through change from own vehicle to public transportation was found to be equally beneficial for health promotion compared to aerobic exercise.
Purpose The valuable impacts of exercise-intervention in diverse type of cancer patients were rationally well-prescribed, though many experimental and review researches already performed in this fields. Generally, cancer-related fatigue and pain remains one of the most prevalent problems for cancer populations. Therefore, exercise has become increasingly significant in cancer prevention and progression. The purpose of this recent study was to analyze the combined exercise program on cancer-related fatigue, pain, quality of life and cancer prognosis in diverse type of cancer patients. This study analyses the safety and feasibility of exercise intervention in diverse stages of cancer patients such as early stage, advanced stage and even metastatic periods in cancer populations. we also wanted to know the impacts of dose-response trial of aerobic and resistance exercise on quality of life in cancer survivors. Methods we conducted a comprehensive PubMed/MEDILINE electronic database from Jan 2015 to August 2020. The reference lists of eligible experimental research articles and relevant systemic review articles were checked. Inclusion criteria were adult cancer survivors from randomized controlled trials performing well-tailored exercise intervention programs to diverse type of cancer patients, Using predefined search items ‘exercise-intervention, cancer & immunology’. Based on reference search, more than 100 articles were identified whereas 30 research papers met the inclusion criteria and were well connected with exercise-intervention and cancer progression. we analyzed the connections between physical exercise and cancer intervention in the main text. Results Moderate to vigorous exercise (aerobic and resistance exercise) revealed to decreased level of cancer-related fatigue, pain, and cancer-related symptoms, however increased level of sleep quality, activities of daily living, exercise performance and health- related quality of life. Exercise intervention reduced pro-inflammatory markers and oxidative stress as well as insomnia, fatigue, pain symptoms whereas it enhanced the antioxidant systems and immune functions. In addition, home-based aerobic physical exercise might enhance muscular strength and quality of life in many types of cancer survivors. Psychological intervention also effective for reducing cancer-related fatigue and pain during and after cancer treatment. they might be the much better intervention than available pharmaceutical options. we believe that it is the related mechanisms of immune cell mobilization and activation such as NK cells which is induced by the activation of sympathetic system during and after physical exercise. Conclusion According to the aforementioned results, it was concluded that implementation of exercise intervention appear to be the best non-pharmaceutical interventions for cancer populations, and also revealed to be safe and feasible in early and advanced stages, although not in the metastatic periods. Sometimes, psychological intervention such as mindfulness-based stress reduction (MBSR) might be useful in reducing anxiety, depression, fatigue, pain and enhancing quality of life, quality of sleep for cancer populations. we can conclude, exercise-intervention might not just be prevention effect but might be therapeutics, however more studies are urgently needed to confirm the exercise intervention on the NK-receptors activation and immune connection of cancer populations.
