Purpose The study was designed to investigate the effects of 12 weeks of circuit training and L-tryptophan supplementation on physical fitness and metabolic syndrome. Methods Forty-one menopausal women were randomly assigned to one of three groups. i.e., combined circuit training and L-tryptophan supplementation group (CT+T: n=14), L-tryptophan supplementation group (T: n=14), and control group (CON: n=13). The subjects in CT+T exercised three sessions per week and took 3g of L-tryptophan per day for 12 weeks. The subjects in T took 3g of L-tryptophan per day for 12 weeks. The subjects in CON were asked to maintain their life pattern for the same period of intervention. Physical fitness and metabolic syndrome-related variables were measured at pre- and post-test. The data were compared by utilizing a repeated two-way ANOVA. Results Main results of the study were as follows: 1) Standing long jump, one leg standing with eyes closed, sit-and-reach, sit-up, and maximal oxygen uptake increased significantly in CT+T. 2) Body weight, body mass index, waist circumference, waist-hip ratio, fat mass, and percent body fat decreased significantly in CT+T. 3) Total cholesterol decreased significantly in CT+T. 4) Fasting plasma glucose (FPG), fasting plasma insulin, and HOMA-IR decreased significantly in CT+T. FPG and HOMA-IR decreased significantly in T. 5) Systolic blood pressure, diastolic blood pressure (DBP), mean arterial pressure (MAP), and rate pressure product decreased significantly in CT+T. DBP and MAP decreased significantly in T. 6) Number of metabolic syndrome risk factors decreased significantly in CT+T and T. Conclusion It was concluded that the circuit training and L-tryptophan supplementation would have positive effects on physical fitness and metabolic syndrome, and that L-Tryptophan supplementation would have positive effects on metabolic syndrome by improving insulin resistance and hypertension in menopausal women.
Purpose The purpose of this study was to examine the effects of 16 weeks’ combined exercise training on insulin resistance, inflammatory markers, oxidative stress, leukocyte telomere length, body composition, and daily living fitness in elderly women with type 2 diabetes mellitus (DM). Methods Twenty-eight participants were randomly assigned into one of two groups, i.e., exercise training group (EX: n=14) and control group (CON: n=14). Subjects in EX participated in 3 sessions of 60 min-combined exercise for 16 weeks, whereas subjects in CON were asked to maintain their normal life pattern during the same period. The variables regarding insulin resistance, inflammatory markers, oxidative stress, leukocyte telomere length, body composition, and daily living fitness were measured and compared between two groups as well as between pre-post test utilizing a repeated two-way ANOVA. Results Main results were as follows: 1) Fasting plasma insulin and HOMA-IR tended to decrease in EX, whereas increased significantly in CON. 2) IL-6, TNF-α, hs-CRP decreased in EX, but the changes were not statistically significant. 3) MDA increased significantly and GPx decreased significantly in both EX and CON. 4) Leukocyte telomere length increased significantly in EX. 5) Fat-free mass increased in EX, whereas fat mass and percent body fat decreased significantly in EX. 6) Arm curl, chair stand, sit & reach, tandem test, 10m walking speed, and up & go improved significantly in EX. Conclusion It was concluded that the combined exercise for 16 weeks had a positive effect on improving insulin resistance, increasing leukocyte telomere length, as well as enhancing body composition and daily living fitness in elderly women with type 2 diabetes.
