Purpose The present study compared physical fitness, metabolic syndrome risk factors, and resting metabolic rate (RMR) according to body mass index (BMI) and percent body fat (%BF) in 20s females. Methods Fifty-one women in their 20s were recruited and assigned into three groups, i.e., normal group (n=18), normal weight obesity (NWO) group (n=18), and obesity group (n=15) according to BMI and %BF. Physical fitness, metabolic syndrome risk factors, and RMR were measured and compared among three groups. Results Main results were as follows: 1) Physical fitness were not significantly different among three groups. 2) Regarding 1-RM, arm curl and leg extension were significantly lower in normal group and NWO group than obesity group. Leg press was significantly lower in normal group than obesity group. 3) Regarding metabolic syndrome risk factors, there were significant differences in waist circumference, ordering from low to high such as normal, NWO, and obesity groups. Systolic blood pressure and diastolic blood pressure were significantly lower in normal group and NWO group than obesity group, while HDL-C was significantly higher in normal group than NWO group and obesity group. 4) Regarding RMR, absolute values of RMR such as VO2(㎖·min-1), RMR (Kcal·min-1), RMR (KJ·min-1), and RMR (Kcal·day-1) were significantly lower in normal group and NWO group than obesity group. On the other hand, relative value of RMR such as RMR (KJ·kg-1FW·h-1) was significantly higher in normal group than NWO group and obesity group. Conclusions It was concluded that obese women showed increased risk of metabolic syndrome and low relative RMR level, and NWO had similar problems. Active health management through physical activity and dietary control should be committed to NWO individuals because the NWO has possibility of high risk of metabolic syndrome and reduction of metabolic rate from 20s even though there was no problem in their external appearance.
Purpose The purpose of this study was to examine the effects of 16 weeks’ combined exercise training on insulin resistance, inflammatory markers, oxidative stress, leukocyte telomere length, body composition, and daily living fitness in elderly women with type 2 diabetes mellitus (DM). Methods Twenty-eight participants were randomly assigned into one of two groups, i.e., exercise training group (EX: n=14) and control group (CON: n=14). Subjects in EX participated in 3 sessions of 60 min-combined exercise for 16 weeks, whereas subjects in CON were asked to maintain their normal life pattern during the same period. The variables regarding insulin resistance, inflammatory markers, oxidative stress, leukocyte telomere length, body composition, and daily living fitness were measured and compared between two groups as well as between pre-post test utilizing a repeated two-way ANOVA. Results Main results were as follows: 1) Fasting plasma insulin and HOMA-IR tended to decrease in EX, whereas increased significantly in CON. 2) IL-6, TNF-α, hs-CRP decreased in EX, but the changes were not statistically significant. 3) MDA increased significantly and GPx decreased significantly in both EX and CON. 4) Leukocyte telomere length increased significantly in EX. 5) Fat-free mass increased in EX, whereas fat mass and percent body fat decreased significantly in EX. 6) Arm curl, chair stand, sit & reach, tandem test, 10m walking speed, and up & go improved significantly in EX. Conclusion It was concluded that the combined exercise for 16 weeks had a positive effect on improving insulin resistance, increasing leukocyte telomere length, as well as enhancing body composition and daily living fitness in elderly women with type 2 diabetes.
[Purpose] The purpose of this study was to examine the change of muscle damage markers after maximal eccentric exercise and to verify the difference of recovery according to ACTN3 gene polymorphism. [Methods] Fifty healthy males participated in this study. Subjects performed 25 times/1 set (total 2 set) maximal eccentric contractions of the elbow flexor muscles on a modified preacher curl machine with a between-sets rest time of 5 min. Maximal isometric contraction (MIC) was measured 6 times (pre, post, after 24 h, 48 h, 72 h and 96 h). Muscle soreness (SOR) was measured 5 times (pre, after 24 h, 48 h, 72 h and 96 h). Blood samples were collected 5 times (pre, after 24 h, 48 h, 72 h and 96 h). ACTN3 gene polymorphisms were identified using polymerase chain reaction (PCR). Data were analyzed using a 2-way repeated measure ANOVA and post hoc Bonferroni test. [Results] Analysis of ACTN3 gene polymorphism revealed the following distribution: 22% RR (n=11), 50% RX (n=25), and 28% XX (n=14). Individuals were classified into the RR homozygote group (n=11) and the X-allele group (n=39). MIC showed a significant difference between groups and interaction (p<.05). The groups differed significantly in MIC at 48 h, 72 h, and 96 h after exercise and the X-allele group decreased more than the RR homozygote group. The groups differed significantly in muscle soreness and interaction (p<.05). SOR in the X-allele group was significantly higher than in the RR homozygote group at 24 h after exercise. Although blood CK activity was lower in the RR homozygote group than in the X-allele group, but there was no significant difference between the groups (p>.05). [Conclusion] The RR homozygote group showed lower muscle strength reduction rate, muscle soreness and blood CK activity than the X-allele group. This indicates that RR individuals have a lower risk of exercise-induced muscle damage than those with an X-allele.
Purpose The purpose of this study were to assess physiological and biochemical characteristics in elderly women with osteosarcopenic obesity (OSO), and to analyze relationships among irisin, adipokines and bone metabolism markers. Methods 126 elderly women were selected and among them 10 women were classified into OSO group (76.9±5.2 yrs) and 14 women were classified as a NOSO group (72.9±5.6 yrs). Physique, body composition and bone mineral density were measured. Senior fitness tests were 30-s chair stand, 30-s arm curl, chair sit-and-reach, back scratch, 8-foot up-and-go, grip strength, and 2-min step test. Isokinetic muscle strength was measured by isokinetic dynamometer (Cybex 770, USA). Nutrition intake and physical activity were administered. Biochemical parameters including irisin, FNDC-5, leptin, adiponectin, CTx, 25(OH)D, osteocalcin, and PTH were measured. All data were analyzed by SAS 9.4. Independent t-test was applied to compare between OSO and NOSO groups. Multiple regression analysis was used. The level of significance was set at .05. Results The results of the study showed that there were significantly high for waist circumference, hip circumference, WHR, and BMI in OSO group compared to those of NOSO group. Higher results were also obtained for fat tissue and percent body fat but significantly low for lumbar bone mineral density. OSO group showed significant lower results for grip strength and 2-min step test compared to NOSO group. Peak torque, and relative peak torque at 60° were significantly lower for left and right knee flexion in OSO group. Protein intake was significantly low in OSO group, but no difference was obtained in level of physical activity between two groups. Irisin was significantly related to adiponectin, FNDC-5 and osteocalcin in explaining 35.2%, 81.5% and 92.1% of the variance, respectively. Conclusions This study shows that elderly women with OSO have higher results for physique and body composition parameters except body height. However, lower values were obtained for functional fitness, and isokinetic muscle strength. OSO may have more risks for metabolic syndrome, bone fractures, fall, lack of daily physical activity and limit of locomotion due to the imbalance of quadriceps and biceps femoris in non dominant leg. This study suggests that criteria and mechanism of OSO should be clarified by follow-up study.
