The cerebellum is one of the major parts of the brain involved in the motor control including motor coordination, muscle tone, balance, and the learning of motor skills. The purpose of this review paper was to explore of pathophysiology, anatomical function and neurophysiological mechanism for cerebellum. For this, we sought to examine of previous study related cerebellar disease. Specifically, this paper suggested that motor deficiency of limb movements, coordination, gait/posture balance, adaptation of during movement execution through information proprioception or kinaesthesia, and motor planning and programming of cerebellar patients. We expect that this review will be able to offer the useful information to research. For example, movement scientists will provide an academic information about cerebellar ataxia. Patients and their families will provide relevant information to the daily life (e.g., management and rehabilitation exercise).
PURPOSE The purpose of this study was to investigate the characteristics of field and on-ice performances of ice-hockey players and the relationship of performance with subjective joint pain and dysfunction. METHODS A total of 25 male college icehockey players were evaluated for 19 items of performance. Pain and dysfunctions in the lower extremities and lower back were confirmed through the Foot and Ankle Outcome Score, Knee Injury and Osteoarthritis Outcome Score, Hip Dysfunction and Osteoarthritis Outcome Score, and Osweatry Disability Index questionnaire. Players with similar performance characteristics were classified through a cluster analysis, and differences in performance and patient-reported outcomes between clusters were analyzed with a one-way analysis of variance. RESULTS The ice-hockey players were classified into “lower muscular strength and performance (cluster 1),” “lower cardiorespiratory endurance (cluster 2),” and “high muscular strength and performance (cluster 3).” Players in cluster 1 had more frequent ankle and knee joint dysfunctions and pain compared to those in cluster 3. Several performance test items affected the subjective joint score, and the related performance items were more in the proximal joint than in the distal joint. CONCLUSIONS Ice hockey players should perform training to supplement their individual lack of on-ice and field performance. Since performance may be limited because of joint dysfunction and pain, a joint-specific intervention strategy should be applied to improve physical and athletic performances.
Purpose Prostate problems, such as prostate cancer, and benign prostate hyperplasia have been recognized as problems largely related to androgens and genetic factors. They affect a large fraction of the elderly population, contributing significantly to morbidity and mortality. Therefore, the purpose of this review paper was to investigate a therapeutic strategies for prostate cancer and benign prostate hyperplasia. Methods In order to determine the therapeutic exercise strategies for prostate cancer and benign prostate hyperplasia, previous literature was reviewed with MEDLINE, PubMed, and Scopus databases. Results Prostate cancer and its associated treatments can cause significant and lasting morbidities, such as cardiovascular and sexual dysfunctions. Various interventions have attempted to prevent or mitigate these dysfunctions. This review summarizes the available evidence concerning the effects of exercise training on male sexual health in the cancer prevalent population. Smoking cessation, regular exercise, and maintaining healthy weight are important public health targets for intervention. Importantly, several lifestyle modifications may lower the risk of developing more aggressive cancer or offer survival benefits to prostate cancer patients. Conclusions In this review article, physical exercise training can increase apoptosis markers in the prostate, suggesting exercise training as a potential novel therapeutic strategies for treating prostate cancer and benign prostate hyperplasia. Future studies in more advanced and varied prostate cancer populations are required to ascertain the duration, intensity and frequency of exercise that optimizes the effects of exercise training on prostate cancer and benign prostate hyperplasia.
Purpose The purpose of this study was to investigate the effect of treadmill exercise and MitoQ treatment on NADPH oxidase, antioxidation and vascular function-related factors in aortic of D-galactose-induced aging rats. Methods To induce the animal model of aging, D-galactose was diluted in saline, and a dose of 100mg /kg was intraperitoneally injected into Sprague-Dawley rats once a day for a total of 10 weeks. Rats were divided into five groups: Control group (CON, n=9), D-galactose control group (DC, n=9), D-galactose+MitoQ group (DM, n=9), D-galactose+Exercise group (DE, n=9), D-galactose+MitoQ + Exercise group(DME, n=9), and treadmill exercise was conducted for 5 days/week during 8 weeks with gradual increase of intensity. MitoQ treatment was intraperitoneally injected at a concentration of 100μM/kg twice a week for 8 weeks during the research period. Results The result showed that treadmill exercise and MitoQ treatment decreased the expression of NADPH oxidase level and increased antioxidant enzyme such as SOD-2, catalase. It lead to positive effects such as increasing the level of eNOS, a protein involved in vascular function while decreasing the level of VCAM-1. In addition, as a result, it showed the structurally reduced intima-media thickness. Conclusions It can be concluded that treadmill exercise and MitoQ treatment are effective in ameliorating and treating vascular dysfunction resulting from aging.
Purpose The purpose of this study was to investigate the effects of coupled high frequency rTMS and prism illusion in elderly stroke patients, based on the result of previous studies which discovered the effect of bilateral training, mirror rehabilitation treatment, and rTMS. Methods This is a case study of 4 stroke patients who were homogeneous on the basis of selection criteria such as brain injury area, duration of onset, degree of upper limb movement function. A total of 24 rehabilitation sessions were conducted three times a week during the training period, and TMS(transcranial magnetic stimulator), EMG, motion analysis system, and prism optical glasses were used for apparatus. Results The results of the study were as follows: Combined rehabilitation exercises were found to be beneficial to restore upper limb function in stroke patients. Particularly, the maximum speed of stretching and JTT(Jebsen-taylor Test) performance showed improvement after training. The amount of total map volume and MEP(megnetic evoked potential) increased in evaluation of neurophysiology. Conclusion The upper limb dysfunction of stroke patients could be restored by combine rehabilitation exercises.
Purpose The aim of this study was to investigate the effects of treadmill exercise on mitochondrial quality control in the APP/sw transgenic mice model of Alzheimer's disease(AD). Methods The experimental mice were divided into non-tg-control (NTC, n=10), tg-control (TC, n=10), and tg-exercise (TE, n=10), and treadmill exercise was conducted for 12 weeks (15m/min, 60min, 5 times/week). And then, we measured the cognitive function using MWM and the brain cortex was evaluated to determine whether any changes in the oligomer Aβ, apoptotic-related factors, mitophagy and mitochondrial biogenesis. Results As a result, treadmill exercise significantly reduced oligomer amyloid and also had a positive effect on proteins (PUMA, Bax, Bcl-2) associated with apoptosis. In addition, through the treadmill exercise, PINK-1 decreased, and increased parkin, showing that active inhibition of mitophagy has been partially relaxed. It has been confirmed that the key autophagy markers LC3 and p62 significantly reduce p62 expression in TE group compared to TC group, and that LC3-II/LC3-I ratio tended to decrease, although not significant, increasing the activity of mitophagy. Next, proteins related to mitochondrial biosynthesis (SIRT-1, PGC-1α, Tfam, and COX-IV) have been identified, and the treadmill exercise has confirmed that the expression of all proteins has increased in part. Finally, cognitive has been shown to improve cognitive by shortening both swimming distance and time through treadmill exercise. Conclusions Thus, our finding suggested treadmill exercise alleviates cognitive dysfunction by improving mitochondrial quality control(mitophagy, mitochondrial biogenesis) and neuronal cell death via reducing amyloid accumulation, which may play a role in a preventive strategy for AD.
PURPOSE The purpose of this review was to summarize the current knowledge on the trends in athletes’ health problems (and their preventive strategies) caused by low energy availability (LEA) and relative energy deficiency in sports (RED-S). METHODS In this narrative review, we summarized previous studies by searching the literature in the PubMed, Google Scholar, and Science Direct databases. RESULTS Energy availability (EA) refers to the amount of energy from caloric intake used for exercise, and a LEA is considered as a surrogate marker of RED-S. In several previous studies, chronic low energy availability in female athletes has been reported to cause health problems such as endocrine dysfunctions, immunosuppression, and psychological disorders, and to also affect the hypothalamic-pituitary-gonadal (HPC) axis and bone health. Moreover, it has been suggested that an increase in injury risk and a decrease in exercise performance may occur. CONCLUSIONS Since it can be difficult to recover from the health deteriorations caused by RED-S, early detection (of related signs and symptoms) and prevention are very important. Therefore, athletes, coaches, and parents need to develop educational programs that ease the recognition of the problems caused by various symptoms related to RED-S and promote educational interventions.
